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Brief Report
- Ebola Hemorrhagic Fever and the Current State of Vaccine Development
- Joo Eun Hong, Kee-Jong Hong, Woo Young Choi, Won-Ja Lee, Yeon Hwa Choi, Chung-Hyeon Jeong, Kwang-il Cho
- Osong Public Health Res Perspect. 2014;5(6):378-382. Published online December 31, 2014
- DOI: https://doi.org/10.1016/j.phrp.2014.09.006
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Abstract
PDF - Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with Ebola Hemorrhagic Fever (EHF) was continuously increasing even though the any effective therapeutics or vaccines has not been developed yet. The Ebola virus in Guinea showed 98% homology with Zaire Ebola Virus.Study of the pathogenesis of Ebola virus infection and assess of the various candidates of vaccine have been tried for a long time, especially in United States and some European countries. Even though the attenuated live vaccine and DNA vaccine containing Ebola viral genes were tested and showed efficacy in chimpanzees, those candidates still need clinical tests requiring much longer time than the preclinical development to be approved for the practical treatment.It can be expected to eradicate Ebola virus by a safe and efficient vaccine development similar to the case of smallpox virus which was extinguished from the world by the variola vaccine.
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Citations
Citations to this article as recorded by
- Recent developments and strategies of Ebola virus vaccines
Ashish Ranjan Sharma, Yeon-Hee Lee, Sudarshini Nath, Sang-Soo Lee
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Jiangen He, Chaomei Chen
Frontiers in Research Metrics and Analytics.2018;[Epub] CrossRef - Social network analysis and modeling of cellphone-based syndromic surveillance data for Ebola in Sierra Leone
Jia B. Kangbai
Asian Pacific Journal of Tropical Medicine.2016; 9(9): 851. CrossRef - El desarrollo de nuevas vacunas
Fernando González-Romo, Juan J. Picazo
Enfermedades Infecciosas y Microbiología Clínica.2015; 33(8): 557. CrossRef - Out of Africa, Into Global Health Security Agenda
Hae-Wol Cho, Chaeshin Chu
Osong Public Health and Research Perspectives.2014; 5(6): 313. CrossRef
- Recent developments and strategies of Ebola virus vaccines
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